Understanding how fat storage affects cancer spread
Lipid storage and catabolism as drivers of metastatic invasion
This study is looking at how pancreatic cancer cells use stored fats for energy to help them spread, with the hope of finding new ways to stop the cancer from spreading and improve treatment options for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10931621 on NIH RePORTER |
What this research studies
This research investigates the role of lipid storage and metabolism in the spread of pancreatic cancer. It aims to uncover the molecular mechanisms that allow cancer cells to use stored fats as energy during their invasive migration. By studying how these lipid droplets are broken down and utilized by tumor cells, the research seeks to identify new therapeutic targets that could help inhibit cancer metastasis. Patients may benefit from insights that could lead to innovative treatments aimed at improving survival rates.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with pancreatic cancer who are experiencing or at risk of metastatic disease.
Not a fit: Patients with non-cancerous conditions or those with cancers not related to lipid metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly reduce cancer metastasis and improve patient survival.
How similar studies have performed: Other research has shown promising results in targeting metabolic pathways in cancer, suggesting potential for success in this novel approach.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Razidlo, Gina Lynn — Mayo Clinic Rochester
- Study coordinator: Razidlo, Gina Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.