Understanding how differences in aneurysm tissue affect growth and rupture risk
Official title: Role of mechanical heterogeneity in cerebral aneurysm growth and rupture
Funded at University of Minnesota · NIH-11004650 · Data updated 2026-11-12
This study is looking at how the strength and behavior of cerebral aneurysms can help us better understand which ones might burst, so that patients can get the right care at the right time.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | January 15, 2023 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $444,429 |
| NIH project number | 5R01NS126762-03 |
| Project ID | NIH-11004650 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with cerebral aneurysms who are at varying risk levels for rupture.
✕Less likely to help
Patients with other types of vascular conditions unrelated to cerebral aneurysms may not benefit from this research.
What this research studies
This research investigates the mechanical properties of cerebral aneurysms to better predict their risk of rupture. By examining how variations in tissue mechanics influence aneurysm behavior, the study aims to improve existing models that currently rely on simpler factors like shape and blood flow. Patients with cerebral aneurysms may benefit from this research as it seeks to develop more accurate assessments for determining which aneurysms are at risk of rupture, potentially leading to timely interventions. The approach involves advanced computational modeling and analysis of blood flow dynamics to understand the underlying mechanics of aneurysm stability.
Why it matters
Potential benefit: If successful, this research could lead to improved prediction of cerebral aneurysm rupture, allowing for better-targeted treatments and reducing unnecessary surgeries.
How similar studies have gone: Previous research has shown promise in using mechanical properties to predict aneurysm behavior, but this approach is still evolving and aims to enhance existing methodologies.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Alford, Patrick W — University of Minnesota
- Study coordinator: Alford, Patrick W
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.