Understanding how cold affects platelet transfusions
Official title: Role of TRPM8 in Cold-stored Platelet Transfusions
Funded at Bloodworks · NIH-10917132 · Data updated 2026-11-12
This study is looking at how platelets, which are important for blood clotting, react to cold temperatures and a special receptor called TRPM8, with the goal of finding better ways to store platelets for transfusions, making them safer and more effective for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bloodworks NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | August 1, 2020 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $586,949 |
| NIH project number | 5R01HL153072-05 |
| Project ID | NIH-10917132 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include patients who require platelet transfusions, particularly those with conditions affecting blood clotting or undergoing surgeries.
✕Less likely to help
Patients who do not require platelet transfusions or have conditions unrelated to platelet function may not benefit from this research.
What this research studies
This research investigates how platelets respond to cold temperatures, focusing on a specific receptor called TRPM8 that is activated by cold stimuli. By studying the molecular pathways involved, the research aims to improve the storage conditions for platelets used in transfusions, potentially leading to safer and more effective treatments. The approach includes characterizing the role of TRPM8 in platelets and how it influences their function when exposed to cold. This could enhance our understanding of platelet behavior during transfusions and in conditions requiring temperature management.
Why it matters
Potential benefit: If successful, this research could lead to improved platelet transfusion practices, enhancing patient safety and outcomes.
How similar studies have gone: Preliminary studies have shown promising results regarding the role of TRPM8 in platelets, suggesting that this approach may lead to significant advancements in transfusion practices.
Where this research is happening
-
Bloodworks
Seattle, United States Active
Researchers
- Principal investigator: Stolla, Moritz — Bloodworks
- Study coordinator: Stolla, Moritz
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.