Metabolically Active Extracellular Mitochondria and Brain Injury-Related Vessel Dysfunction
Official title: Metabolically Aberrant Extracellular Mitochondria and Oxidative Endotheliopathy after Traumatic Brain Injury
Funded at Bloodworks · NIH-11342305 · Data updated 2026-11-12
This research aims to understand how tiny energy-producing particles released after brain injury damage blood vessels and contribute to clotting problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bloodworks NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | July 1, 2026 |
| Project end | April 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $724,351 |
| NIH project number | 1R01HL185679-01 |
| Project ID | NIH-11342305 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with acute brain injury or those at risk of TBI-related vascular complications; future translational steps may involve monitoring or targeting endothelial pathways.
✕Less likely to help
Individuals without brain injury or vascular complications related to TBI are unlikely to benefit.
What this research studies
After a traumatic brain injury, blood vessels often leak and become prone to clots. This project studies how extracellular mitochondria released from injured brain tissue enter endothelial cells, trigger stress responses, and disrupt normal cell function. The team will explore the steps from mitochondria uptake to cell death and increased vascular leak, with the goal of linking these processes to problems in blood clotting after injury. Findings could point to new targets to protect the brain and blood vessels after TBI.
Why it matters
Potential benefit: If successful, the research could reveal new strategies to prevent vascular damage and abnormal clotting after brain injury, potentially improving recovery.
How similar studies have gone: There is prior evidence linking endothelial dysfunction and brain injury, but the specific role of extracellular mitochondria in this context is being explored and remains under investigation.
Where this research is happening
-
Bloodworks
Seattle, United States Active
Researchers
- Principal investigator: Dong, Jing-Fei — Bloodworks
- Study coordinator: Dong, Jing-Fei
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.