Understanding von Willebrand disease and sickle cell disease
Molecular and Translational Studies in Hematologic Disorders
Researchers are looking at how pieces of a blood protein called von Willebrand factor and oxidized fats in sickle cell blood affect bleeding and vessel blockages in people with von Willebrand disease and sickle cell disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Bloodworks NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11291298 on NIH RePORTER |
What this research studies
This project focuses on two blood conditions: von Willebrand disease (VWD) and sickle cell disease (SCD). Scientists will examine small fragments of von Willebrand factor and the role of the enzyme ADAMTS13 in VWD, while also studying oxidized lipids from sickled red blood cells and blood lipoproteins in SCD. The work uses laboratory experiments with blood and blood-derived materials to see how these fragments and oxidized fats change platelet, white cell, and vessel responses. Findings are intended to connect laboratory discoveries to patient blood behaviors and potential clinical implications.
Who could benefit from this research
Good fit: People with diagnosed von Willebrand disease (especially types 2A or 2B) or with sickle cell disease who are willing to provide blood samples would be the best candidates to participate.
Not a fit: People without bleeding disorders or sickle cell disease, or those unable to give blood, are unlikely to receive direct benefit from this research.
Why it matters
Potential benefit: If successful, this work could point to new tests or targets that reduce bleeding in VWD or prevent vaso-occlusive events in SCD.
How similar studies have performed: Previous research supports roles for von Willebrand factor and oxidized lipids in these diseases, but the specific functions of the small VWF fragments and some oxidized lipids are relatively new and not yet proven in patients.
Where this research is happening
Seattle, United States
- Bloodworks — Seattle, United States (Active)
Researchers
- Principal investigator: Lopez, Jose Aron — Bloodworks
- Study coordinator: Lopez, Jose Aron
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.