Understanding how certain viruses evade the immune system
The B22 family of orthopoxvirus virulence factors: Investigating structure/function of these potent, multifaceted immunoevasins
This study is looking at certain proteins made by viruses like smallpox and monkeypox to see how they help the viruses hide from our immune system, which could lead to better ways to prevent or treat these infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11030280 on NIH RePORTER |
What this research studies
This research investigates the B22 family of proteins produced by orthopoxviruses, which include dangerous viruses like smallpox and monkeypox. The study aims to understand how these proteins help the viruses evade the immune system, particularly by affecting the function of key immune cells. By using animal models, researchers will explore the structure and function of these proteins to uncover their role in virulence and immune evasion. This knowledge could lead to new strategies for preventing or treating infections caused by these viruses.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk of infections from orthopoxviruses, including healthcare workers and those in close contact with infected individuals.
Not a fit: Patients with no exposure risk to orthopoxviruses or those with unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved vaccines or therapies against serious viral infections.
How similar studies have performed: Previous research has shown success in understanding viral immune evasion mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Eisenlohr, Laurence Crane — Children's Hosp of Philadelphia
- Study coordinator: Eisenlohr, Laurence Crane
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.