Understanding how cells divide and produce force during separation
Official title: Mechanisms of force production in cytokinesis
Funded at North Carolina State University Raleigh · NIH-11010984 · Data updated 2026-11-12
This study is looking at how cells split into two, focusing on the tiny structures that help them do this, and it could help us understand more about cell division and its connection to diseases like cancer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | North Carolina State University Raleigh NIH-funded |
| Lab location | 1 site (Raleigh, United States) |
| Project start | June 1, 2025 |
| Project end | April 30, 2030 |
| Funding year | 2025 |
| Award (this year) | $454,367 |
| NIH project number | 1R35GM156520-01 |
| Project ID | NIH-11010984 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions related to abnormal cell division, such as certain cancers or fibrotic diseases.
✕Less likely to help
Patients with conditions unrelated to cell division or those not experiencing cancer or fibrotic diseases may not benefit from this research.
What this research studies
This research investigates the process of cytokinesis, where a single cell divides into two daughter cells. It focuses on the role of actin filaments and myosin in generating the forces necessary for this separation. By employing advanced techniques such as genetics, quantitative cell biology, and biophysics, the researchers aim to uncover the molecular mechanisms that drive this critical process. The findings could provide insights into how cell division is regulated and its implications for diseases like cancer.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for targeting cell division in cancer and fibrotic diseases.
How similar studies have gone: Other research has shown success in understanding cell division mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
North Carolina State University Raleigh
Raleigh, United States Active
Researchers
- Principal investigator: Laplante, Caroline — North Carolina State University Raleigh
- Study coordinator: Laplante, Caroline
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.