Understanding how capillary barriers function in critically ill children
Molecular regulation of the capillary barrier in acute critical illness
This study is looking at how capillary leak syndrome affects critically ill children and aims to understand how certain signals in the body can weaken blood vessel barriers, with the hope of finding new ways to help these kids feel better and recover faster.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10875434 on NIH RePORTER |
What this research studies
This research investigates the mechanisms behind capillary leak syndrome in acutely critically ill children, a condition that can lead to worsening organ failure despite treatment. The study aims to identify the specific cellular responses and signaling pathways involved in this process, particularly focusing on how certain cytokines affect the integrity of blood vessel barriers. By examining cultured human endothelial cells, researchers hope to uncover potential therapeutic targets that could improve patient outcomes. The ultimate goal is to enhance understanding of the pathophysiology of capillary leak and develop better treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research are critically ill children experiencing acute organ failure and capillary leak syndrome.
Not a fit: Patients with chronic illnesses or those not experiencing acute critical conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for critically ill children suffering from organ dysfunction due to capillary leak syndrome.
How similar studies have performed: While there have been studies on cytokine responses in critically ill patients, this research aims to explore novel pathways that have not been extensively tested.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Pierce, Richard W — Yale University
- Study coordinator: Pierce, Richard W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.