Understanding how brain circuits influence decision making
Official title: Molecular and functional architecture of a premotor circuit for decision making
Funded at Icahn School of Medicine at Mount Sinai · NIH-11014049 · Data updated 2026-11-12
This study is looking at how different brain cells in a part of the brain that helps with decision-making work together in mice, to learn more about how genetics might affect these connections and how they relate to issues like addiction and depression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $529,224 |
| NIH project number | 5R01MH133039-03 |
| Project ID | NIH-11014049 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals experiencing cognitive deficits associated with addiction, major depression, or other psychiatric conditions.
✕Less likely to help
Patients without cognitive impairments or those not affected by addiction or related psychiatric disorders may not benefit from this research.
What this research studies
This research investigates the complex interactions between different types of brain cells and their connections in the premotor cortex, which is crucial for decision making. By studying mice, the researchers aim to uncover how genetic factors shape the organization and function of these brain circuits. The goal is to better understand the cognitive deficits associated with psychiatric disorders such as addiction and depression. Through advanced behavioral paradigms, the study will explore how these neural circuits contribute to complex behaviors.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for cognitive impairments related to addiction and other mental health disorders.
How similar studies have gone: Previous research has shown promising results in understanding brain circuits related to decision making, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Wu, Zheng Herbert — Icahn School of Medicine at Mount Sinai
- Study coordinator: Wu, Zheng Herbert
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.