Understanding how atopic dermatitis progresses in children
Official title: Atopic dermatitis: mechanisms of disease progression
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11063101 · Data updated 2026-11-12
This study is looking at how atopic dermatitis, a common skin issue in kids, can affect their overall health and lead to allergies, by tracking how things like skin, gut, and breathing health play a role in its development.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | April 20, 2020 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $224,999 |
| NIH project number | 5U01AI152034-06 |
| Project ID | NIH-11063101 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have been diagnosed with atopic dermatitis.
✕Less likely to help
Patients who do not have atopic dermatitis or are older than 11 years may not benefit from this research.
What this research studies
This research investigates the mechanisms behind atopic dermatitis (AD), a common skin condition in children that can lead to other allergic diseases. By following a cohort of children with AD, the study aims to explore how factors like skin, gut, and airway health contribute to the progression of this condition. The research employs advanced techniques to categorize different types of AD and predict future allergic outcomes, providing insights into how AD develops over time.
Why it matters
Potential benefit: If successful, this research could lead to better prevention and treatment strategies for atopic dermatitis and related allergic conditions in children.
How similar studies have gone: Previous research has shown promise in understanding atopic dermatitis and its progression, but this specific approach is novel and aims to provide deeper insights.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Khurana Hershey, Gurjit K. — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Khurana Hershey, Gurjit K.
Related research
Other NIH-funded projects on the same topics.
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Stopping Atopic Dermatitis and Allergy: Preventing Food Allergy by Protecting the Skin
A large study in infants at high risk for allergies tests whether using a skin barrier cream together with early, proactive skin care can prevent peanut allergy and other food allergies.
-
SEAL Study: Preventing peanut allergy by protecting baby skin
This trial tests whether using a skin-emollient and proactive skin steroids early in life can prevent peanut allergy in high-risk infants.
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SEAL Study: Prevent allergy by protecting the baby’s skin
A very young group of high-risk babies will try a early skin-care plan to reduce eczema and prevent peanut allergy.
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Understanding how skin fungi affect atopic dermatitis in adults
A study will look at how the skin's fungal community influences atopic dermatitis in adults and whether this understanding could lead to new treatments.
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Preventing eczema-related allergies by strengthening infants' skin barrier
This project will see if using a trilipid skin cream plus proactive mild topical steroids in infants with early dry skin or eczema lowers their chances of developing food allergies.
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Personalized predictions for how atopic dermatitis may progress in kids and teens
A patient-friendly plan to forecast how early-onset eczema might evolve in children and young people using simple health clues and data from diverse settings.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.