Personalized predictions for how atopic dermatitis may progress in kids and teens
Official title: Personalized Prediction of Atopic Dermatitis Disease Course Across Diverse Settings
Funded at University of California, San Francisco · NIH-11418025 · Data updated 2026-11-12
A patient-friendly plan to forecast how early-onset eczema might evolve in children and young people using simple health clues and data from diverse settings.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 19, 2025 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $198,645 |
| NIH project number | 5R01AR085315-02 |
| Project ID | NIH-11418025 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are children with early-onset atopic dermatitis and their family members who participate in pediatric dermatology or allergy care.
✕Less likely to help
Patients with already resolved eczema or those not contributing data to the cohorts may not benefit.
What this research studies
If you or your child has early-onset atopic dermatitis, this study aims to predict who will have ongoing symptoms or develop related allergies or neuropsychiatric issues. Researchers will build easy-to-get prognostic models from early-life information and test them across birth cohorts in Uganda, Ecuador, and the UK to see if a single model works well in different places. They will also explore more detailed predictors like genetic risks and environmental factors to see if they improve predictions. The work uses machine learning but focuses on outcomes that matter to families, such as persistent disease and associated conditions.
Why it matters
Potential benefit: If successful, clinicians could better counsel families and design smarter trials for new eczema treatments.
How similar studies have gone: Prior work using cohort data and machine learning shows promise in predicting chronic eczema trajectories, but generalizability across diverse settings is still being tested.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Abuabara, Katrina Elaine — University of California, San Francisco
- Study coordinator: Abuabara, Katrina Elaine
Related research
Other NIH-funded projects on the same topics.
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Stopping Atopic Dermatitis and Allergy: Preventing Food Allergy by Protecting the Skin
A large study in infants at high risk for allergies tests whether using a skin barrier cream together with early, proactive skin care can prevent peanut allergy and other food allergies.
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SEAL Study: Preventing peanut allergy by protecting baby skin
This trial tests whether using a skin-emollient and proactive skin steroids early in life can prevent peanut allergy in high-risk infants.
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SEAL Study: Prevent allergy by protecting the baby’s skin
A very young group of high-risk babies will try a early skin-care plan to reduce eczema and prevent peanut allergy.
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Understanding how skin fungi affect atopic dermatitis in adults
A study will look at how the skin's fungal community influences atopic dermatitis in adults and whether this understanding could lead to new treatments.
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Preventing eczema-related allergies by strengthening infants' skin barrier
This project will see if using a trilipid skin cream plus proactive mild topical steroids in infants with early dry skin or eczema lowers their chances of developing food allergies.
-
Sodium in the Skin and Atopic Dermatitis
This grant looks at how salt in the skin relates to eczema and whether reducing salt could help people with atopic dermatitis.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.