Understanding how altered microRNA affects lymphatic malformations
Official title: Altered miRNA Expression Drives Proliferation of Lymphatic Malformation by Activating Pro-Growth Signaling Cascades
Funded at Arkansas Children's Hospital Res Inst · NIH-10929306 · Data updated 2026-11-12
This study is looking at how changes in tiny molecules called microRNAs might affect lymphatic malformations, which are birth defects that can cause health problems, and it aims to find new ways to help treat people dealing with these issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arkansas Children's Hospital Res Inst NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | August 25, 2023 |
| Project end | August 24, 2027 |
| Funding year | 2024 |
| Award (this year) | $39,354 |
| NIH project number | 5F30HL165803-02 |
| Project ID | NIH-10929306 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with lymphatic malformations, particularly those with complications from traditional treatments.
✕Less likely to help
Patients without lymphatic malformations or those whose conditions are unrelated to the molecular mechanisms being studied may not benefit from this research.
What this research studies
This research investigates the role of altered microRNA expression in lymphatic malformations, which are complex congenital lesions that can cause significant health issues. By examining the molecular mechanisms involved, particularly focusing on the PIK3CA gene and its impact on lymphatic endothelial cells, the study aims to uncover new therapeutic targets. The approach includes advanced techniques such as miRNA sequencing and proteomics to analyze the differences between affected and normal cells. This comprehensive analysis could lead to better treatment options for patients suffering from these conditions.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies that more effectively treat lymphatic malformations.
How similar studies have gone: While the specific approach of this research is novel, similar studies have shown promise in understanding and treating other vascular malformations.
Where this research is happening
-
Arkansas Children's Hospital Res Inst
Little Rock, United States Active
Researchers
- Principal investigator: Sun, Ravi — Arkansas Children's Hospital Res Inst
- Study coordinator: Sun, Ravi
Related research
Other NIH-funded projects on the same topics.
-
Shorter antifungal treatment for kids with candidemia
A multi-center pediatric trial tests whether a shorter, 7 extra days of antifungal therapy after an initial 7 days is just as good as the standard 14-day approach for kids with candidemia who are improving on echinocandin therapy.
-
Short Course vs Standard Course Antifungal Therapy for Pediatric Candidemia
This study tests whether a shorter 7-day total antifungal treatment after an initial 7 days of echinocandin therapy is as effective as the usual 14-day course for children with candidemia.
-
Shorter antifungal treatment for kids with candidemia
A multi-center study tests whether kids with candidemia can finish treatment earlier after an initial week of antifungal therapy than the standard two weeks total.
-
Shorter antifungal treatment for kids with candidemia
This study tests whether children with candidemia can finish treatment after 7 days of an echinocandin if they are improving, instead of completing a full 14 days.
-
Shorter antifungal course for kids with candidemia
A multi-center study tests whether 7 extra days of antifungal therapy after an initial week of treatment can be shortened safely for children with candidemia.
-
Shortened antifungal treatment for kids with candidemia
A pediatric multicenter trial will test whether stopping antifungal therapy after 7 more days, following an initial 7 days of treatment, isas safe as continuing for 14 days.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.