Understanding how altered microRNA affects lymphatic malformations
Altered miRNA Expression Drives Proliferation of Lymphatic Malformation by Activating Pro-Growth Signaling Cascades
This study is looking at how changes in tiny molecules called microRNAs might affect lymphatic malformations, which are birth defects that can cause health problems, and it aims to find new ways to help treat people dealing with these issues.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arkansas Children's Hospital Res Inst NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project ID | NIH-10929306 on NIH RePORTER |
What this research studies
This research investigates the role of altered microRNA expression in lymphatic malformations, which are complex congenital lesions that can cause significant health issues. By examining the molecular mechanisms involved, particularly focusing on the PIK3CA gene and its impact on lymphatic endothelial cells, the study aims to uncover new therapeutic targets. The approach includes advanced techniques such as miRNA sequencing and proteomics to analyze the differences between affected and normal cells. This comprehensive analysis could lead to better treatment options for patients suffering from these conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with lymphatic malformations, particularly those with complications from traditional treatments.
Not a fit: Patients without lymphatic malformations or those whose conditions are unrelated to the molecular mechanisms being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of novel therapies that more effectively treat lymphatic malformations.
How similar studies have performed: While the specific approach of this research is novel, similar studies have shown promise in understanding and treating other vascular malformations.
Where this research is happening
Little Rock, United States
- Arkansas Children's Hospital Res Inst — Little Rock, United States (Active)
Researchers
- Principal investigator: Sun, Ravi — Arkansas Children's Hospital Res Inst
- Study coordinator: Sun, Ravi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.