Understanding how aging affects acute myeloid leukemia
Official title: Impact of the senescent bone marrow microenvironment in AML biology
Funded at Temple Univ of the Commonwealth · NIH-11191602 · Data updated 2026-11-12
This study is looking at how the aging bone marrow affects the growth of acute myeloid leukemia (AML) in older adults, with the goal of finding new ways to improve treatment for patients with this condition.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | February 1, 2024 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $249,000 |
| NIH project number | 5R00CA246083-05 |
| Project ID | NIH-11191602 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 55 and older who have been diagnosed with acute myeloid leukemia.
✕Less likely to help
Patients with acute myeloid leukemia who are younger than 55 years old may not benefit from this research.
What this research studies
This research investigates the role of the aging bone marrow microenvironment in the progression of acute myeloid leukemia (AML), particularly in older adults. The study aims to understand how supportive cells in the bone marrow, which are altered by aging, contribute to the development and resistance of leukemia. By examining the interactions between aging cells and leukemia cells, the researchers hope to identify new therapeutic targets that could improve treatment outcomes for patients with AML. The approach includes analyzing the molecular changes in bone marrow cells associated with aging and leukemia.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve survival rates and quality of life for older adults with acute myeloid leukemia.
How similar studies have gone: While there has been some research on aging and leukemia, this specific focus on the bone marrow microenvironment in older adults is relatively novel and untested.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Abdul-Aziz, Amina — Temple Univ of the Commonwealth
- Study coordinator: Abdul-Aziz, Amina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.