Understanding how a specific protein regulates cell cycle progression
Official title: PP2A/B55alpha substrate specificity and function in cell cycle progression
Funded at Temple Univ of the Commonwealth · NIH-10946400 · Data updated 2026-11-12
This study is looking at how a specific protein called PP2A/B55α helps control cell growth and division, which is important for understanding diseases like cancer and Alzheimer's, and it aims to find out how this protein interacts with other molecules in our cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Temple Univ of the Commonwealth NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2024 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $661,956 |
| NIH project number | 1R01GM155497-01 |
| Project ID | NIH-10946400 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related conditions that involve cell cycle dysregulation.
✕Less likely to help
Patients with conditions unrelated to cell cycle regulation or those not diagnosed with Alzheimer's disease may not benefit from this research.
What this research studies
This research investigates the role of the PP2A/B55α protein in recognizing its substrates and regulating the cell cycle. By exploring the molecular mechanisms involved, the study aims to identify how this protein influences cell signaling and progression through the cell cycle, which is crucial in conditions like cancer and Alzheimer's disease. The approach involves detailed biochemical assays to uncover the interactions between PP2A/B55α and its substrates, focusing on a newly discovered helical motif that plays a key role in these processes.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the treatment of diseases like Alzheimer's and cancer by targeting the mechanisms of cell cycle regulation.
How similar studies have gone: Previous research has shown promising results in understanding protein interactions in cell signaling, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Temple Univ of the Commonwealth
Philadelphia, United States Active
Researchers
- Principal investigator: Grana, Xavier — Temple Univ of the Commonwealth
- Study coordinator: Grana, Xavier
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.