Understanding how a specific protein helps a virus replicate.
Official title: Characterizing the role of CSDE1 as a critical co-factor for VSV replication.
Funded at Mayo Clinic Rochester · NIH-11030257 · Data updated 2026-11-12
This study is looking at how a specific protein in our cells helps the Vesicular Stomatitis Virus (VSV) replicate, and it aims to find out how some cells can resist the virus after being exposed for a long time, which could lead to new ways to treat infections.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | March 20, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $391,395 |
| NIH project number | 5R01AI170535-03 |
| Project ID | NIH-11030257 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with viral infections or certain types of cancer who may benefit from virotherapy.
✕Less likely to help
Patients with non-viral related conditions or those not affected by cancer may not receive any benefit from this research.
What this research studies
This research investigates the role of the CSDE1 protein in the replication of the Vesicular Stomatitis Virus (VSV). By studying how cells can escape viral replication after prolonged exposure to VSV, researchers have identified mutations that affect the virus's ability to replicate. The study employs advanced techniques like RNA sequencing to analyze these mutations and their impact on both the virus and the host cells. This work aims to uncover new insights into viral behavior and potential therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for viral infections and cancer therapies that utilize viruses to target cancer cells.
How similar studies have gone: Other research has shown promise in using viral therapies for cancer treatment, indicating that this approach may yield beneficial results.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Vile, Richard G. — Mayo Clinic Rochester
- Study coordinator: Vile, Richard G.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.