Understanding how a specific protein affects egg development and fertility.
Elucidating the mechanism by which Elastin Microfibril interface-located protein 1 (EMILIN1) contributes to folliculogenesis
This study is looking at how a protein called EMILIN1 might help improve egg growth for people with premature ovarian insufficiency (POI), using special materials from cow ovaries to potentially boost fertility options for those having trouble getting pregnant.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Lurie Children's Hospital of Chicago NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project ID | NIH-10997060 on NIH RePORTER |
What this research studies
This research focuses on premature ovarian insufficiency (POI), a condition that leads to infertility due to decreased ovarian function. The study aims to explore the role of a protein called EMILIN1 in the development of ovarian follicles, which are essential for egg maturation. By using advanced biomaterials derived from bovine ovarian tissue, the researchers hope to enhance follicle growth and improve the quality of eggs in laboratory settings. This could lead to better fertility preservation techniques for individuals facing challenges in conceiving.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing premature ovarian insufficiency or those seeking to preserve their fertility due to medical conditions or treatments.
Not a fit: Patients who are not experiencing fertility issues or those who have already achieved successful pregnancies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved fertility preservation methods for individuals with premature ovarian insufficiency.
How similar studies have performed: Previous research has shown promise in using biomaterials for enhancing fertility outcomes, suggesting that this approach could yield significant advancements.
Where this research is happening
Chicago, United States
- Lurie Children's Hospital of Chicago — Chicago, United States (Active)
Researchers
- Principal investigator: Mcdowell, Hannah — Lurie Children's Hospital of Chicago
- Study coordinator: Mcdowell, Hannah
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.