Understanding how a specific protein affects brain communication and function
Official title: Elucidating the dynamic role of PTPsigma in synaptic nano-organization and NMDA receptor function
Funded at University of Maryland Baltimore · NIH-11093568 · Data updated 2026-11-12
This study is looking at how a protein called PTPsigma helps organize connections between brain cells that are important for learning and memory, which could help us understand issues related to autism and anxiety.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | May 1, 2023 |
| Project end | February 28, 2026 |
| Funding year | 2025 |
| Award (this year) | $38,810 |
| NIH project number | 5F31NS129086-03 |
| Project ID | NIH-11093568 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with autism spectrum disorder or related anxiety disorders.
✕Less likely to help
Patients with conditions unrelated to synaptic transmission or those without neurological disorders may not benefit from this research.
What this research studies
This research investigates the role of a protein called PTPsigma in the organization of synapses, which are critical for communication between brain cells. By examining how this protein influences the positioning of receptors involved in learning and memory, the study aims to uncover mechanisms that could be disrupted in conditions like autism and anxiety disorders. The approach involves advanced techniques to visualize and analyze the arrangement of proteins at synapses, providing insights into their function and potential therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for autism spectrum disorder and related conditions by enhancing our understanding of synaptic function.
How similar studies have gone: Previous research has shown promising results in understanding synaptic mechanisms, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Demarco, Emily M. — University of Maryland Baltimore
- Study coordinator: Demarco, Emily M.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.