Genetics and function of inherited brain disorders that affect thinking and behavior
Official title: Genetics and Functional Studies of Autosomal Recessive Neurological Disorders
Funded at University of Maryland Baltimore · NIH-11594180 · Data updated 2026-11-12
Scientists are studying how genes and cellular helpers shape brain development and why certain kids have intellectual disabilities and adaptive-behavior challenges.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | July 1, 2018 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $52,467 |
| NIH project number | 3R01NS107428-08S1 |
| Project ID | NIH-11594180 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with cognitive dysfunction or intellectual disability and their families who may benefit from improved genetic understanding and future therapies.
✕Less likely to help
People whose condition is not linked to the studied genes or whose participation does not lead to a direct clinical benefit.
What this research studies
This grant builds on prior work to discover new genes linked to cognitive disorders and to understand how those genes affect neuron structure and brain function. Researchers will examine genetic variants and the proteins they produce to see how they influence neural networks involved in learning and everyday skills. The work uses brain biology tools, computational analyses, and cellular models to connect genetic findings to how the brain develops and works in health and disease. Outcomes could lead to better genetic tests and new strategies to prevent or treat cognitive dysfunction.
Why it matters
Potential benefit: Potentially improved diagnosis and new targets for therapies that support brain development and cognitive function.
How similar studies have gone: Previous work has identified many genes associated with cognitive function, and this renewal aims to expand that genetic repertoire and clarify gene roles in neurons.
Where this research is happening
-
University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Riazuddin, Saima — University of Maryland Baltimore
- Study coordinator: Riazuddin, Saima
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.