NPRL2 loss and focal cortical dysplasia in epilepsy
Official title: The role of NPRL2 loss in focal cortical dysplasia
Funded at University of Maryland Baltimore · NIH-11617796 · Data updated 2026-11-12
This grant investigates how losing NPRL2 in the brain contributes to focal cortical dysplasia and epilepsy in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $46,726 |
| NIH project number | 3R01NS131223-04S1 |
| Project ID | NIH-11617796 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with focal cortical dysplasia or related mTOR-pathway–linked brain conditions could benefit from advances stemming from this research.
✕Less likely to help
This basic science project may not directly help patients immediately; translational steps would come later.
What this research studies
Researchers will study NPRL2 loss both in lab models and in living systems to understand how it changes brain cell behavior and the mTOR pathway. They will look at gene activity and molecular signals that happen when NPRL2 is missing, aiming to map out how these changes lead to the cortical abnormalities seen in some patients. The work could point to new ways to treat epilepsy caused by these brain changes in the future. Participation would involve laboratory studies and potential future translational steps that bring findings closer to patient care.
Why it matters
Potential benefit: Understanding NPRL2-related brain changes could guide new approaches to treating epilepsy linked to focal cortical dysplasia.
How similar studies have gone: Previous work shows NPRL2-related pathway changes can drive mTOR hyperactivation and epilepsy, but functional validation for NPRL2 variants is still emerging.
Where this research is happening
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University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Iffland, Philip Henry — University of Maryland Baltimore
- Study coordinator: Iffland, Philip Henry
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.