Understanding how a parasite forms infectious cysts
Identification and characterization of early encystation genes in the human parasite Entamoeba histolytica
This study is looking at how the parasite that causes amoebic dysentery makes infectious cysts to survive and spread, which could help us find new ways to treat the infection and improve care for patients.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project ID | NIH-10880541 on NIH RePORTER |
What this research studies
This research investigates the mechanisms by which the human parasite Entamoeba histolytica forms infectious cysts, which are crucial for its survival and spread. By establishing a laboratory system to study the encystation process, researchers aim to identify the genes involved in this transformation. The study focuses on how the parasite adapts to different environments, particularly within the human large intestine, to enhance its ability to cause disease. Patients may benefit from insights gained about the parasite's lifecycle and potential targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been diagnosed with infections caused by Entamoeba histolytica or are at risk of such infections.
Not a fit: Patients who do not have any history of Entamoeba histolytica infection or related gastrointestinal diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for infections caused by Entamoeba histolytica, such as amoebic dysentery.
How similar studies have performed: While research on related parasites has shown some success, the specific mechanisms of encystation in Entamoeba histolytica are less understood, making this a novel area of investigation.
Where this research is happening
Clemson, United States
- Clemson University — Clemson, United States (Active)
Researchers
- Principal investigator: Ingram-Smith, Cheryl Jean — Clemson University
- Study coordinator: Ingram-Smith, Cheryl Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.