Tissue Structure and Nerve Changes in the Sacroiliac Joint
Official title: Tissue Structural and Neural Remodeling in Human Sacroiliac Joint
Funded at Clemson University · NIH-11621205 · Data updated 2026-11-12
Researchers are studying how the sacroiliac joint contributes to low back pain by looking at its tissue structure and nerve-related changes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project start | September 15, 2018 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $217,890 |
| NIH project number | 5P20GM121342-09 |
| Project ID | NIH-11621205 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults experiencing low back pain where SIJ involvement is suspected may be eligible, especially those with unclear diagnoses or overlapping SIJ symptoms.
✕Less likely to help
Individuals without sacroiliac joint–related pain or those not meeting study criteria may not experience direct benefit.
What this research studies
This project focuses on understanding how the sacroiliac joint biomechanically supports the body and how its tissues and nerves may contribute to pain. Using 3-D anatomical analysis and tissue studies, the team aims to link structural features with pain mechanisms in people with low back pain. The work combines human tissue insights with imaging and biomechanical data to improve diagnosis and guide therapies for SIJ-related pain.
Why it matters
Potential benefit: Better understanding of SIJ pain could lead to more accurate diagnoses and targeted treatments for patients suffering from low back pain linked to the sacroiliac joint.
How similar studies have gone: Previous work suggests that integrating biomechanics and tissue biology can reveal mechanisms of pain, supporting potential benefits of this approach.
Where this research is happening
-
Clemson University
Clemson, United States Active
Researchers
- Principal investigator: Chen, Peng — Clemson University
- Study coordinator: Chen, Peng
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.