Understanding how a chemical affects early development in embryos
Uncovering the Role of Histone Acetylation in Tetrabromobisphenol A-induced Developmental Toxicity during Zygotic Genome Activation
This study looks at how a common flame retardant called TBBPA affects the early development of zebrafish embryos, helping us understand how it might cause problems in growth and development that could be important for human health.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project ID | NIH-11062361 on NIH RePORTER |
What this research studies
This research investigates the effects of a common flame retardant, tetrabromobisphenol A (TBBPA), on early embryonic development using zebrafish as a model organism. The study focuses on how TBBPA disrupts the activation of the zygotic genome, which is crucial for normal development, and examines the role of histone acetylation in this process. By analyzing genetic and epigenetic changes, the researchers aim to uncover the mechanisms through which TBBPA causes developmental delays and defects. The findings could provide insights into the long-term health impacts of exposure to this chemical during critical developmental windows.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals concerned about the effects of environmental toxins on child development, particularly those with exposure to flame retardants.
Not a fit: Patients who are not affected by environmental toxins or those without concerns about developmental health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of developmental issues caused by environmental toxins in children.
How similar studies have performed: Previous research has shown that similar approaches using model organisms can successfully reveal the impacts of environmental toxins on development.
Where this research is happening
Clemson, United States
- Clemson University — Clemson, United States (Active)
Researchers
- Principal investigator: Dasgupta, Subham — Clemson University
- Study coordinator: Dasgupta, Subham
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.