Understanding how a chemical affects early development in embryos
Official title: Uncovering the Role of Histone Acetylation in Tetrabromobisphenol A-induced Developmental Toxicity during Zygotic Genome Activation
Funded at Clemson University · NIH-11062361 · Data updated 2026-11-12
This study looks at how a common flame retardant called TBBPA affects the early development of zebrafish embryos, helping us understand how it might cause problems in growth and development that could be important for human health.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Clemson University NIH-funded |
| Lab location | 1 site (Clemson, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $73,594 |
| NIH project number | 5R03ES036327-02 |
| Project ID | NIH-11062361 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals concerned about the effects of environmental toxins on child development, particularly those with exposure to flame retardants.
✕Less likely to help
Patients who are not affected by environmental toxins or those without concerns about developmental health issues may not benefit from this research.
What this research studies
This research investigates the effects of a common flame retardant, tetrabromobisphenol A (TBBPA), on early embryonic development using zebrafish as a model organism. The study focuses on how TBBPA disrupts the activation of the zygotic genome, which is crucial for normal development, and examines the role of histone acetylation in this process. By analyzing genetic and epigenetic changes, the researchers aim to uncover the mechanisms through which TBBPA causes developmental delays and defects. The findings could provide insights into the long-term health impacts of exposure to this chemical during critical developmental windows.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention of developmental issues caused by environmental toxins in children.
How similar studies have gone: Previous research has shown that similar approaches using model organisms can successfully reveal the impacts of environmental toxins on development.
Where this research is happening
-
Clemson University
Clemson, United States Active
Researchers
- Principal investigator: Dasgupta, Subham — Clemson University
- Study coordinator: Dasgupta, Subham
Related research
Other NIH-funded projects on the same topics.
-
Tissue Structure and Nerve Changes in the Sacroiliac Joint
Researchers are studying how the sacroiliac joint contributes to low back pain by looking at its tissue structure and nerve-related changes.
-
Regulation of Cryptosporidium Development in Kids and Communities
Scientists are studying how Cryptosporidium, a parasite that causes severe diarrhea from dirty water, develops, with the goal of finding new treatments for people who get sick.
-
ATTRACT: How jaw shape and movement affect jaw joint health in adults with jaw misalignment
This project studies how the shape and movement of the jawbone in adults with Class II or III jaw misalignment relate to the health and mechanics of the jaw joint.
-
Noninvasive nanoparticle therapy for the peripheral nervous system
Aimed at improving delivery of non-invasive treatments to injured nerves, this grant funds equipment to study how nanoparticles can cross the blood-nerve barrier and support nerve repair.
-
Health Extension for Diabetes: Connecting Community and Clinic
A community-clinical program aims to improve diabetes care by linking local health resources with clinical services over a two-year period.
-
Ice-free Preservation and Nanowarming for Viable Meniscal Transplants
Aimed at helping people with serious knee meniscus damage by improving how donor meniscal tissue is preserved so it stays alive longer.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.