Understanding how a brief intervention can prevent suicide.

Neural Mechanisms and Predictors of an Ultra-Brief Suicide Prevention Strategy

NIH-funded research Ohio State University · NIH-11078250

This study is looking at how a one-time crisis response planning session can help adults who are feeling very suicidal by improving their ability to handle emotions and stress, and it aims to find ways to make suicide prevention more effective in different healthcare settings.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionOhio State University NIH-funded
Lab location1 site (Columbus, UNITED STATES)
Project IDNIH-11078250 on NIH RePORTER

What this research studies

This research investigates the effectiveness of a single session of crisis response planning (CRP) in reducing suicidal behavior among adults with active suicidal intent. By examining the neural mechanisms and predictors of changes in suicidality, the study aims to identify how CRP strengthens emotional regulation and reduces stress reactivity. Participants will undergo assessments of brain function and psychophysiological responses to better understand the intervention's impact. The goal is to optimize suicide prevention strategies that can be widely implemented across various medical settings.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults over 21 years old who are experiencing active suicidal thoughts.

Not a fit: Patients who are not currently experiencing suicidal thoughts or behaviors may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to more effective suicide prevention strategies that save lives.

How similar studies have performed: Previous research has shown promising results with crisis response planning, but this study aims to explore novel neural mechanisms that have not been tested before.

Where this research is happening

Columbus, UNITED STATES

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Last reviewed 2026-06-09 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.