Understanding how 3D structures in DNA affect leukemia and lymphoma
Mapping and targeting 3D regulatory elements in leukemia and lymphoma
This study is looking at how the way our DNA is organized can affect the development and treatment of leukemia and lymphoma, with the hope of finding new ways to tailor treatments based on each patient's unique genetic makeup.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11070765 on NIH RePORTER |
What this research studies
This research investigates the role of 3D chromatin architecture in the development and treatment response of leukemia and lymphoma. By examining how genetic and epigenetic changes influence the structure of DNA, the study aims to identify critical regulatory elements that could be targeted for therapy. The approach includes advanced techniques to analyze chromatin interactions and their impact on gene expression, particularly in T-cell acute lymphoblastic leukemia. Patients may benefit from insights that could lead to more effective treatment strategies based on their unique genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with acute T-cell leukemia or lymphoma who are seeking innovative treatment options.
Not a fit: Patients with other types of cancer or those not diagnosed with acute T-cell leukemia or lymphoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatments for patients with leukemia and lymphoma.
How similar studies have performed: Other research has shown promise in targeting epigenetic modifications in cancer, suggesting that this approach could yield significant advancements.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Aifantis, Iannis — New York University School of Medicine
- Study coordinator: Aifantis, Iannis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.