3D gene switches in leukemia and lymphoma
Mapping and targeting 3D regulatory elements in leukemia and lymphoma
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11248036
Researchers will map and try to block 3D gene-control hubs that help T-cell leukemia and lymphoma cells grow, aiming to find new ways to help people with these cancers.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11248036 on ClinicalTrials.gov |
What this research studies
The team will study how DNA folds in leukemia and lymphoma cells to find spots, or "hubs," that control important cancer genes. They will use advanced lab methods to map connections between enhancers and promoters and to look at epigenetic marks and long noncoding RNAs that shape these hubs. The work will test ways to disrupt these hubs in cell models and in tumor samples to see how cancer cells respond. Findings could point to new targets or markers for future treatments.
Who could benefit from this research
Good fit: Ideal candidates would be people diagnosed with T-cell acute lymphoblastic leukemia or related T-cell lymphomas who can provide tumor samples or consent to genomic/epigenetic testing.
Not a fit: People without T-cell leukemias or those seeking immediate treatment may not directly benefit, since this is early-stage lab-focused research rather than a treatment trial.
Why it matters
Potential benefit: If successful, this work could point to new targeted treatments or biomarkers to help predict and improve outcomes for people with T-cell leukemias and some lymphomas.
How similar studies have performed: Previous laboratory studies have mapped 3D genome features and shown that disrupting some regulatory hubs can change cancer cell behavior, but therapies targeting these structures remain experimental.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: AIFANTIS, IANNIS — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: AIFANTIS, IANNIS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.