Understanding genetic variation in human tissues
Official title: 'Mosaicism in Human Tissues, from Telomere to Telomere to RFA-22-013: "Somatic Mosaicism across Human Tissues Program: Genome Characterization Centers."
Funded at Seattle Children's Hospital · NIH-11083087 · Data updated 2026-11-12
This study is looking at how genetic changes happen in different parts of the body to help us understand their impact on health and disease, and it’s for anyone interested in how these changes might relate to their own health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Seattle Children's Hospital NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $2,999,999 |
| NIH project number | 5UM1DA058220-03 |
| Project ID | NIH-11083087 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are willing to provide tissue samples and have a keen interest in understanding their genetic health.
✕Less likely to help
Patients with conditions that do not involve somatic genetic variations may not receive direct benefits from this research.
What this research studies
This research investigates the genetic variations that occur in different human tissues, aiming to provide a comprehensive understanding of somatic mosaicism. By analyzing samples from 50 donors across 10 different tissues, the project will utilize advanced sequencing techniques to identify and characterize various types of genetic changes. This approach goes beyond traditional methods that typically focus on a single tissue type, allowing for a more complete picture of how these variations may influence health and disease. Patients may benefit from insights gained about the role of somatic variations in their conditions.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of genetic factors in health and disease, potentially guiding personalized treatment strategies.
How similar studies have gone: Previous research has shown success in characterizing genetic variations using advanced genomic techniques, indicating a promising potential for this approach.
Where this research is happening
-
Seattle Children's Hospital
Seattle, United States Active
Researchers
- Principal investigator: Bennett, James T — Seattle Children's Hospital
- Study coordinator: Bennett, James T
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.