Understanding flu and COVID-19 vaccine responses in people and in the lab

Who could benefit from this research

What this research studies

This project looks at how vaccines for flu and SARS-CoV-2 perform in adults, especially those with higher health risks, by studying antibodies and immune responses. It combines patient-derived data with lab experiments to understand what makes vaccines work well or poorly and to test new antigen designs. The work includes advanced analyses of antibody features and immune signaling, with a focus on improving vaccine effectiveness and durability. The team aims to translate these insights into better vaccine strategies for real-world protection.

Why it matters

Where this research is happening

• Stanford University
  Stanford, United States Active

Researchers

• Principal investigator: Davis, Mark Morris — Stanford University
• Study coordinator: Davis, Mark Morris

Related research

Other NIH-funded projects on the same topics.

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• Vaccine effectiveness in preventing respiratory illness in Washington state (2022–2027)

  This project tests how well vaccines against flu, COVID-19, and other respiratory viruses protect people in Washington state from getting acutely ill.

  NIH research Kaiser Foundation Health Plan of Washington · Seattle, United States · NIH-11379693

• Understanding flu and COVID-19 vaccine responses in adults

  A Stanford-led effort studies how the flu and COVID-19 vaccines work in adults and how to make them work better for people, especially those with higher risk from underlying health conditions.

  NIH research Stanford University · Stanford, United States · NIH-11333210

• How flu, COVID-19, and other respiratory vaccines protect people in Washington from sudden respiratory illness

  This project checks how well seasonal flu, COVID-19, and other respiratory vaccines prevent short-term respiratory illnesses in people living in Washington state.

  NIH research Kaiser Foundation Health Plan of Washington · Seattle, United States · NIH-11170380

• Tracking serious influenza, COVID-19, and other respiratory infections in working-age Indian adults

  This project follows adults aged 18–60 in India who get severe respiratory infections to find out how often they happen, what long-term problems and costs result, and how well vaccines protect against serious illness.

  NIH research All-India Institute of Medical Sciences · New Delhi, India · NIH-11137548

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.