Understanding flu and COVID-19 vaccine responses in adults
Official title: Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro
Funded at Stanford University · NIH-11333210 · Data updated 2026-11-12
A Stanford-led effort studies how the flu and COVID-19 vaccines work in adults and how to make them work better for people, especially those with higher risk from underlying health conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 1, 2003 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $2,200,798 |
| NIH project number | 5U19AI057229-23 |
| Project ID | NIH-11333210 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults 21 years and older, including those with conditions that affect immune responses, who receive or may receive flu or SARS-CoV-2 vaccines.
✕Less likely to help
Individuals not receiving vaccines or those not participating in any associated studies may not directly benefit.
What this research studies
This project examines how bodies respond to flu and COVID-19 vaccines in adults, using both real-life studies and lab experiments to uncover immune factors that influence protection. Researchers will analyze antibody responses, gene signals, and antibody structures to identify ways to improve vaccine effectiveness. The work combines clinical data with laboratory studies to test new antigen designs and computational methods that predict and enhance responses. The goal is to inform next-generation vaccines that provide stronger and longer-lasting protection for diverse populations.
Why it matters
Potential benefit: If successful, the research could lead to more effective vaccines for influenza and SARS-CoV-2, reducing infections and severe illness in adults.
How similar studies have gone: Past studies have shown that understanding antibody structure and glycosylation can improve vaccine design, supporting the potential for meaningful advances here.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Davis, Mark Morris — Stanford University
- Study coordinator: Davis, Mark Morris
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.