Understanding cognitive impairment in multiple sclerosis using advanced modeling techniques
Official title: Computational Model of Neurocognitive Impairment in Multiple Sclerosis
Funded at Icahn School of Medicine at Mount Sinai · NIH-11050525 · Data updated 2026-11-12
This study is looking to create a better way to understand how multiple sclerosis affects thinking skills, not just focusing on how fast you can process information, so that patients can get a clearer picture of their cognitive health and any specific challenges they might face.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | April 1, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $654,287 |
| NIH project number | 1R01NS136523-01A1 |
| Project ID | NIH-11050525 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with relapsing remitting or progressive multiple sclerosis who are experiencing cognitive changes.
✕Less likely to help
Patients with cognitive impairments not related to multiple sclerosis may not benefit from this research.
What this research studies
This research aims to develop a new model to assess cognitive impairment in patients with relapsing remitting and progressive multiple sclerosis (MS). It challenges the traditional view that cognitive processing speed is the main issue, instead exploring various cognitive domains through advanced computational methods. By utilizing the diffusion model, the study seeks to provide a more accurate understanding of cognitive function over time, incorporating recent advancements in MS treatment and diagnostics. This approach will help identify specific cognitive deficits beyond just processing speed, offering a more comprehensive view of cognitive health in MS patients.
Why it matters
Potential benefit: If successful, this research could lead to improved assessment tools for cognitive impairment in MS, enhancing patient care and treatment strategies.
How similar studies have gone: Previous research has shown promise in using computational models to assess cognitive function, indicating potential success for this novel approach.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Sumowski, James Francis — Icahn School of Medicine at Mount Sinai
- Study coordinator: Sumowski, James Francis
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.