Understanding brain structure differences in psychiatric disorders
Official title: Mapping heterogeneity of brain microstructural abnormalities in psychiatric disorders with normative modelling
Funded at Ohio State University · NIH-10918155 · Data updated 2026-11-12
This study is looking at the tiny structures in the brains of people with mental health conditions to create a helpful guide that shows how these structures can vary, which could lead to more personalized treatments for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $562,757 |
| NIH project number | 5R01MH130362-02 |
| Project ID | NIH-10918155 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with psychiatric disorders who are interested in understanding their brain structure and its implications for treatment.
✕Less likely to help
Patients without psychiatric disorders or those who do not wish to participate in research may not benefit from this study.
What this research studies
This research aims to explore the unique characteristics of brain microstructures in individuals with psychiatric disorders by creating a comprehensive reference atlas. Using advanced imaging techniques and data from over 50,000 individuals aged 10 to 100, the project will analyze variations in brain structure and how these relate to psychiatric conditions. The goal is to move towards precision medicine by interpreting individual differences in the context of normal biological variations. A user-friendly web platform will be developed to facilitate access to these findings for researchers and clinicians.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment approaches for psychiatric disorders based on individual brain characteristics.
How similar studies have gone: Previous research has shown promise in using normative modeling techniques to understand brain structure, indicating that this approach could yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Kraguljac, Nina Vanessa — Ohio State University
- Study coordinator: Kraguljac, Nina Vanessa
Related research
Other NIH-funded projects on the same topics.
-
Whole-chromosome fine-mapping across diverse ancestries to understand psychiatric disorders
A study to pinpoint the exact genetic changes that contribute to bipolar disorder and related conditions by using diverse populations to improve accuracy.
-
Neuronal signals guiding deep brain stimulation for neuropsychiatric disorders
A doctor-scientist at Stanford plans to study how deep brain stimulation changes brain cells and circuits in people with OCD, depression, and movement disorders to improve how DBS therapies work.
-
How a spouse's mental health and substance use may affect a partner's drinking problems
A study looks at how a spouse’s psychiatric disorders and drinking habits influence when a person starts, stops, or relapses into alcohol use problems within marriage.
-
Mapping brain microstructure in psychiatric disorders with normal ranges
A study will build a brain-mapping reference to understand how an individual’s brain differs within the normal range, with a focus on youths and how age and sex affect brain microstructure.
-
Foundation Models for Brain Imaging in Psychiatry
A large AI model will be trained on many brain scans and related data to help researchers understand ADHD, autism, and bipolar disorder.
-
How early pollution and stress change brain circuits for motivation and memory
This work looks at how early-life exposure to pollution and stress can alter brain circuits that control motivation and working memory for people with ADHD, depression, or similar conditions.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.