Understanding brain structure differences in psychiatric disorders
Mapping heterogeneity of brain microstructural abnormalities in psychiatric disorders with normative modelling
This study is looking at the tiny structures in the brains of people with mental health conditions to create a helpful guide that shows how these structures can vary, which could lead to more personalized treatments for everyone.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project ID | NIH-10918155 on NIH RePORTER |
What this research studies
This research aims to explore the unique characteristics of brain microstructures in individuals with psychiatric disorders by creating a comprehensive reference atlas. Using advanced imaging techniques and data from over 50,000 individuals aged 10 to 100, the project will analyze variations in brain structure and how these relate to psychiatric conditions. The goal is to move towards precision medicine by interpreting individual differences in the context of normal biological variations. A user-friendly web platform will be developed to facilitate access to these findings for researchers and clinicians.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with psychiatric disorders who are interested in understanding their brain structure and its implications for treatment.
Not a fit: Patients without psychiatric disorders or those who do not wish to participate in research may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to more personalized treatment approaches for psychiatric disorders based on individual brain characteristics.
How similar studies have performed: Previous research has shown promise in using normative modeling techniques to understand brain structure, indicating that this approach could yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- Ohio State University — Columbus, United States (Active)
Researchers
- Principal investigator: Kraguljac, Nina Vanessa — Ohio State University
- Study coordinator: Kraguljac, Nina Vanessa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.