Mapping brain microstructure in psychiatric disorders with normal ranges
Official title: Mapping heterogeneity of brain microstructural abnormalities in psychiatric disorders with normative modelling
Funded at Ohio State University · NIH-11372272 · Data updated 2026-11-12
A study will build a brain-mapping reference to understand how an individual’s brain differs within the normal range, with a focus on youths and how age and sex affect brain microstructure.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $581,849 |
| NIH project number | 5R01MH130362-04 |
| Project ID | NIH-11372272 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates include individuals across the lifespan whose brain imaging data are being studied for psychiatric concerns, particularly those around 10 years old and older.
✕Less likely to help
Participants not connected to psychiatric research or without brain imaging data may not directly benefit.
What this research studies
This project aims to create a reference atlas of brain microstructure across the lifespan using publicly available data from thousands of individuals. It uses normative modeling to interpret personal brain patterns in the context of age- and sex-based norms. The team plans to develop tools, including a web-based ecosystem and user-friendly interfaces, so researchers can apply the models to new datasets. The work could help clinicians and researchers better understand why people respond differently to psychiatric conditions and treatments. Final models, code, and notebooks will be shared to facilitate broader use by the neuroscience community.
Why it matters
Potential benefit: If successful, the work could improve how we interpret individual brain variation in psychiatry, potentially guiding more personalized approaches to diagnosis and treatment.
How similar studies have gone: Other large-scale normative modeling and brain-structure studies have shown the value of comparing individuals to age- and sex-norms in psychiatry.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Kraguljac, Nina Vanessa — Ohio State University
- Study coordinator: Kraguljac, Nina Vanessa
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.