Understanding brain development issues in Fragile X syndrome
Interrogating neurogenic defects in complex assembloid models of fragile X syndrome
This study is looking at how changes in brain development might cause Fragile X syndrome, which affects learning and can be linked to autism, and it hopes to find new ways to help improve brain function for those with the condition.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10727933 on NIH RePORTER |
What this research studies
This research investigates how disruptions in brain development contribute to Fragile X syndrome, a leading cause of inherited intellectual disability and autism. By using advanced human neuronal models, the research aims to explore the effects of a specific protein loss on early brain cell development. The approach includes examining molecular pathways that regulate cell growth and communication in the brain, which could lead to new therapeutic strategies. Patients may benefit from insights gained about potential treatments that could improve brain function and connectivity.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Fragile X syndrome or those with related neurodevelopmental disorders.
Not a fit: Patients without Fragile X syndrome or similar neurodevelopmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve cognitive and behavioral outcomes for individuals with Fragile X syndrome.
How similar studies have performed: Previous research has shown promise in using human neuronal models to study neurodevelopmental disorders, indicating potential for success in this approach.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Raj, Nisha — Emory University
- Study coordinator: Raj, Nisha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.