Understanding and treating Primary Ciliary Dyskinesia
Pathogenesis and Therapeutic Approaches in Primary Ciliary Dyskinesia
This study is looking at a pig model of Primary Ciliary Dyskinesia (PCD) to better understand how the condition affects breathing and to find new ways to help improve the lives of people living with PCD.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11096761 on NIH RePORTER |
What this research studies
This research focuses on Primary Ciliary Dyskinesia (PCD), a genetic condition that affects the movement of cilia, leading to significant respiratory issues. By studying a specially developed pig model that mimics human PCD, researchers aim to uncover the underlying mechanisms of the disease and explore potential therapeutic approaches. The research will investigate early disease development, the impact of impaired ciliary function on cellular metabolism, and the role of specific genes in PCD. The goal is to translate these findings into effective treatments that can improve the quality of life for patients with PCD.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Primary Ciliary Dyskinesia, particularly those experiencing severe respiratory symptoms.
Not a fit: Patients without a diagnosis of Primary Ciliary Dyskinesia or those with other unrelated respiratory conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve respiratory health and overall quality of life for patients with Primary Ciliary Dyskinesia.
How similar studies have performed: Previous research on genetic conditions affecting ciliary function has shown promise in understanding disease mechanisms and developing targeted therapies, suggesting potential for success in this area as well.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Stoltz, David a — University of Iowa
- Study coordinator: Stoltz, David a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.