Understanding and treating Primary Ciliary Dyskinesia
Official title: Pathogenesis and Therapeutic Approaches in Primary Ciliary Dyskinesia
Funded at University of Iowa · NIH-11096761 · Data updated 2026-11-12
This study is looking at a pig model of Primary Ciliary Dyskinesia (PCD) to better understand how the condition affects breathing and to find new ways to help improve the lives of people living with PCD.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project start | June 15, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $2,363,088 |
| NIH project number | 1P01HL172740-01A1 |
| Project ID | NIH-11096761 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Primary Ciliary Dyskinesia, particularly those experiencing severe respiratory symptoms.
✕Less likely to help
Patients without a diagnosis of Primary Ciliary Dyskinesia or those with other unrelated respiratory conditions may not benefit from this research.
What this research studies
This research focuses on Primary Ciliary Dyskinesia (PCD), a genetic condition that affects the movement of cilia, leading to significant respiratory issues. By studying a specially developed pig model that mimics human PCD, researchers aim to uncover the underlying mechanisms of the disease and explore potential therapeutic approaches. The research will investigate early disease development, the impact of impaired ciliary function on cellular metabolism, and the role of specific genes in PCD. The goal is to translate these findings into effective treatments that can improve the quality of life for patients with PCD.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve respiratory health and overall quality of life for patients with Primary Ciliary Dyskinesia.
How similar studies have gone: Previous research on genetic conditions affecting ciliary function has shown promise in understanding disease mechanisms and developing targeted therapies, suggesting potential for success in this area as well.
Where this research is happening
-
University of Iowa
Iowa City, United States Active
Researchers
- Principal investigator: Stoltz, David a — University of Iowa
- Study coordinator: Stoltz, David a
Related research
Other NIH-funded projects on the same topics.
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Personalized therapeutic oligonucleotides for primary ciliary dyskinesia
A new therapy approach uses customized RNA-based medicines to help people with Primary Ciliary Dyskinesia, a rare lung condition, by correcting how genes are read in airway cells.
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Pathogenesis and New Treatments for Primary Ciliary Dyskinesia (PCD)
Researchers are studying why Primary Ciliary Dyskinesia causes lung and airway problems and how to develop better treatments for people with this condition.
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New genes behind primary ciliary dyskinesia
This project looks for new genes that cause primary ciliary dyskinesia to help people with chronic respiratory infections and related complications.
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How a lung cell protein (cytoglobin) affects cilia movement and organ placement
Researchers are looking at whether the airway protein cytoglobin controls nitric oxide and cilia motion in ways that could explain primary ciliary dyskinesia and situs inversus.
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Finding new genes that cause primary ciliary dyskinesia
This study is looking for new genes that cause primary ciliary dyskinesia (PCD), a condition that affects breathing, to help make faster and cheaper tests for it, using a special model from frog embryos to learn more about how cilia work.
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Understanding how a protein affects cilia movement and organ development in airway diseases.
This study is looking at how a protein called cytoglobin helps tiny hair-like structures in your airways work properly, which is important for people with primary ciliary dyskinesia (PCD) and related breathing problems, with the hope of finding better ways to diagnose and treat these conditions.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.