Understanding how a protein affects cilia movement and organ development in airway diseases.
Airway epithelial cytoglobin regulates nitric oxide synthase and development of primary ciliary dyskinesia and situs inversus
This study is looking at how a protein called cytoglobin helps tiny hair-like structures in your airways work properly, which is important for people with primary ciliary dyskinesia (PCD) and related breathing problems, with the hope of finding better ways to diagnose and treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10993662 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called cytoglobin in the development and function of cilia, which are tiny hair-like structures that help clear mucus from the airways. By studying how cytoglobin interacts with nitric oxide synthase (NOS) in both zebrafish and mice, the researchers aim to uncover the mechanisms behind primary ciliary dyskinesia (PCD) and its associated conditions. The study will explore how disruptions in this signaling pathway may lead to chronic respiratory issues and other complications. Patients with PCD may benefit from insights gained through this research, potentially leading to improved diagnostic and therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals diagnosed with primary ciliary dyskinesia or those experiencing chronic respiratory issues related to ciliary dysfunction.
Not a fit: Patients with airway diseases not related to ciliary dysfunction or those without genetic predispositions to PCD may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with primary ciliary dyskinesia and related airway diseases.
How similar studies have performed: Previous research has shown promising results in understanding ciliary function and its implications in respiratory diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Gladwin, Mark T — University of Maryland Baltimore
- Study coordinator: Gladwin, Mark T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.