Understanding how a protein affects cilia movement and organ development in airway diseases.
Official title: Airway epithelial cytoglobin regulates nitric oxide synthase and development of primary ciliary dyskinesia and situs inversus
Funded at University of Maryland Baltimore · NIH-10993662 · Data updated 2026-11-12
This study is looking at how a protein called cytoglobin helps tiny hair-like structures in your airways work properly, which is important for people with primary ciliary dyskinesia (PCD) and related breathing problems, with the hope of finding better ways to diagnose and treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | December 1, 2023 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $627,856 |
| NIH project number | 5R01HL168775-02 |
| Project ID | NIH-10993662 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research include individuals diagnosed with primary ciliary dyskinesia or those experiencing chronic respiratory issues related to ciliary dysfunction.
✕Less likely to help
Patients with airway diseases not related to ciliary dysfunction or those without genetic predispositions to PCD may not receive benefit from this research.
What this research studies
This research investigates the role of a protein called cytoglobin in the development and function of cilia, which are tiny hair-like structures that help clear mucus from the airways. By studying how cytoglobin interacts with nitric oxide synthase (NOS) in both zebrafish and mice, the researchers aim to uncover the mechanisms behind primary ciliary dyskinesia (PCD) and its associated conditions. The study will explore how disruptions in this signaling pathway may lead to chronic respiratory issues and other complications. Patients with PCD may benefit from insights gained through this research, potentially leading to improved diagnostic and therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients with primary ciliary dyskinesia and related airway diseases.
How similar studies have gone: Previous research has shown promising results in understanding ciliary function and its implications in respiratory diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
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University of Maryland Baltimore
Baltimore, United States Active
Researchers
- Principal investigator: Gladwin, Mark T — University of Maryland Baltimore
- Study coordinator: Gladwin, Mark T
Related research
Other NIH-funded projects on the same topics.
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Personalized therapeutic oligonucleotides for primary ciliary dyskinesia
A new therapy approach uses customized RNA-based medicines to help people with Primary Ciliary Dyskinesia, a rare lung condition, by correcting how genes are read in airway cells.
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Pathogenesis and New Treatments for Primary Ciliary Dyskinesia (PCD)
Researchers are studying why Primary Ciliary Dyskinesia causes lung and airway problems and how to develop better treatments for people with this condition.
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New genes behind primary ciliary dyskinesia
This project looks for new genes that cause primary ciliary dyskinesia to help people with chronic respiratory infections and related complications.
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How a lung cell protein (cytoglobin) affects cilia movement and organ placement
Researchers are looking at whether the airway protein cytoglobin controls nitric oxide and cilia motion in ways that could explain primary ciliary dyskinesia and situs inversus.
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Understanding and treating Primary Ciliary Dyskinesia
This study is looking at a pig model of Primary Ciliary Dyskinesia (PCD) to better understand how the condition affects breathing and to find new ways to help improve the lives of people living with PCD.
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Finding new genes that cause primary ciliary dyskinesia
This study is looking for new genes that cause primary ciliary dyskinesia (PCD), a condition that affects breathing, to help make faster and cheaper tests for it, using a special model from frog embryos to learn more about how cilia work.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.