TREM-1 Pathway in COPD-Related Pulmonary Hypertension
Official title: TREM-1 Signaling in COPD with Pulmonary Hypertension
Funded at Birmingham VA Medical Center · NIH-11300017 · Data updated 2026-11-12
This grant explores how a receptor called TREM-1 may drive lung blood vessel changes in people with COPD and pulmonary hypertension, with the goal of finding new ways to help those patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Birmingham VA Medical Center NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project start | April 1, 2026 |
| Project end | March 31, 2030 |
| Funding year | 2026 |
| NIH project number | 1I01RD001549-01A2 |
| Project ID | NIH-11300017 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with COPD who have or are at risk for pulmonary hypertension
✕Less likely to help
People without COPD or pulmonary hypertension or those not represented in the study models may not benefit.
What this research studies
If funded, researchers will study how TREM-1 contributes to abnormal blood vessel remodeling in COPD patients who develop high blood pressure in the lungs. The work includes creating new animal and cell models to mimic COPD-PH and to uncover how TREM-1 triggers inflammation and vascular changes. They will also look at clinical samples to see if TREM-1 levels correlate with disease severity in people with COPD-PH. The findings could point to new targets for therapies that could ease symptoms and improve outcomes for patients. This project is led by the Birmingham VA Medical Center team and builds on prior observations linking TREM-1 to COPD-PH.
Why it matters
Potential benefit: If successful, the research could lead to new treatments that reduce lung vascular remodeling and improve quality of life for COPD patients with pulmonary hypertension.
How similar studies have gone: Previous studies have linked TREM-1 to inflammatory processes in lung disease, and this project expands those findings to COPD-associated PH with new models.
Where this research is happening
-
Birmingham VA Medical Center
Birmingham, United States Active
Researchers
- Principal investigator: Wells, James Michael — Birmingham VA Medical Center
- Study coordinator: Wells, James Michael
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.