Targeting endothelial NOX1 to protect brain blood vessels in Alzheimer's disease
Official title: BBB and neurovascular function modulation by endothelial NOX1 in Alzheimer's Disease
Funded at Louisiana State Univ Hsc Shreveport · NIH-11552217 · Data updated 2026-11-12
This project tests whether blocking NOX1 in brain blood vessel cells can prevent blood flow problems and brain damage in Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Louisiana State Univ Hsc Shreveport NIH-funded |
| Lab location | 1 site (Shreveport, United States) |
| Project start | February 1, 2018 |
| Project end | June 30, 2028 |
| Funding year | 2026 |
| Award (this year) | $196,583 |
| NIH project number | 5P20GM121307-09 |
| Project ID | NIH-11552217 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with or at risk for Alzheimer's disease or dementia, especially those with cerebrovascular involvement, may benefit from future therapies targeting NOX1.
✕Less likely to help
If NOX1 inhibition does not impact vascular function or disease progression, patients may not experience direct benefit from this approach.
What this research studies
Alzheimer's disease involves both brain cell damage and blood flow problems. The study focuses on NOX1 in the lining of brain blood vessels and how its activity contributes to vascular dysfunction in AD models and patients. Researchers will examine what happens when NOX1 is specifically inhibited in endothelial cells, using animal models that mimic AD and analyzing human brain tissue when available. The goal is to identify whether reducing NOX1 activity can protect the brain’s vessels and potentially slow disease progression. Findings could guide development of new therapies aimed at preserving cerebral blood flow in AD.
Why it matters
Potential benefit: If successful, this work could lead to treatments that strengthen brain blood vessels and slow cognitive decline in Alzheimer's patients.
How similar studies have gone: Previous studies have shown NOX enzymes contribute to vascular damage in neurodegenerative models; this project tests a targeted, endothelial-specific approach in AD.
Where this research is happening
-
Louisiana State Univ Hsc Shreveport
Shreveport, United States Active
Researchers
- Principal investigator: Tesic, Vesna — Louisiana State Univ Hsc Shreveport
- Study coordinator: Tesic, Vesna
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.