Targeted HIPK4 degradation for non-hormonal male contraception
Official title: Targeted degradation of HIPK4 for non-hormonal male contraception
Funded at Stanford University · NIH-11462477 · Data updated 2026-11-12
A study to test a new non-hormonal approach that could safely and reversibly reduce male fertility by targeting a testis-specific protein in developing sperm.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | September 15, 2026 |
| Project end | June 30, 2031 |
| Funding year | 2026 |
| Award (this year) | $763,764 |
| NIH project number | 1R01HD120599-01A1 |
| Project ID | NIH-11462477 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adult men interested in future non-hormonal contraception options and who can participate in preclinical research leading toward clinical trials.
✕Less likely to help
Individuals not seeking contraception or those with medical conditions that preclude participation in male reproductive research may not benefit.
What this research studies
This project aims to develop a non-hormonal male contraceptive by selectively degrading HIPK4, a protein important for sperm development. Researchers will explore small molecules that specifically disrupt HIPK4 function in developing sperm cells, seeking reversible contraception with minimal side effects. If successful, this could provide men with a new, reliable option for family planning that doesn’t rely on hormones. The work will involve preclinical experiments in relevant models to assess safety, reversibility, and effectiveness. Results could pave the way for human studies and expanded choices in reproductive health.
Why it matters
Potential benefit: Could lead to a safe, reversible, non-hormonal contraception option for men.
How similar studies have gone: Previous non-hormonal strategies have shown promise in preclinical models but remain early-stage; this approach targets a testis-specific protein for potential improved specificity.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Chen, James K — Stanford University
- Study coordinator: Chen, James K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.