T-helper 2-low asthma in children: finding biomarkers and understanding triggers
Official title: T-helper 2-low pediatric asthma endotypes: omics, biomarkers, and clinical characteristics
Funded at University of Pittsburgh at Pittsburgh · NIH-11411283 · Data updated 2026-11-12
A mentored, five-year career development grant aims to improve diagnosis and understand the causes of T2LOW asthma in children.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | September 1, 2025 |
| Project end | June 30, 2030 |
| Funding year | 2026 |
| Award (this year) | $162,140 |
| NIH project number | 5K08HL177170-02 |
| Project ID | NIH-11411283 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with asthma, especially those suspected of having T2LOW endotypes, may benefit.
✕Less likely to help
Children without asthma or without involvement in T2LOW endotypes may not benefit.
What this research studies
This grant funds Dr. Kristina Gaietto’s plan to advance how we identify and understand T2LOW asthma in kids, a type that has been less studied and often lacks targeted treatments. The project builds on nasal transcriptome work to discover serum biomarkers, explore how violence-related stress might relate to the T17HIGH endotype, and track how endotypes change over 6-12 months. Through mentorship and a structured research program, the work seeks practical insights that could lead to better, more personalized care for children with asthma. The outcome could help clinicians diagnose subtypes more accurately and tailor therapies accordingly.
Why it matters
Potential benefit: If successful, this work could lead to better diagnostic tests and more targeted treatments for children with T2LOW asthma.
How similar studies have gone: Preliminary findings link certain serum proteins to T17HIGH endotypes, supporting the potential for biomarker-based endotyping in asthma.
Where this research is happening
-
University of Pittsburgh at Pittsburgh
Pittsburgh, United States Active
Researchers
- Principal investigator: Gaietto, Kristina — University of Pittsburgh at Pittsburgh
- Study coordinator: Gaietto, Kristina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.