Predicting and Preventing Asthma Exacerbations in Children Exposed to Air Pollution
Official title: Critical Life Event supplement to 'Air pollution sensitivity in pediatric asthma'
Funded at Children's Hosp of Philadelphia · NIH-11424099 · Data updated 2026-11-12
A pediatric-focused project aims to predict which kids with asthma are most at risk for flare-ups when air pollution is high, so clinicians can prevent attacks.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | July 16, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2026 |
| Award (this year) | $47,234 |
| NIH project number | 3K08HL173625-01A1S1 |
| Project ID | NIH-11424099 on NIH RePORTER |
Who could benefit from this research
✓Could help
Children with asthma who are exposed to varying levels of ambient air pollution and for whom genetic, clinical, and social data are available.
✕Less likely to help
Children with asthma who have stable symptoms regardless of pollution or lack access to the necessary data tools may see limited benefit.
What this research studies
This project combines clinical data, genetics, social factors, and environmental exposure to build models that forecast asthma flare-ups in children during days with higher air pollution. Researchers will use existing pediatric patient data to identify which factors most strongly relate to worse asthma outcomes under polluted conditions. The goal is to create practical tools that help doctors tailor prevention strategies for vulnerable kids. The work leverages data science approaches to translate complex data into actionable insights for families and clinicians.
Why it matters
Potential benefit: If successful, clinicians could better prevent asthma flare-ups in pollution-prone children by using predictive alerts and personalized management plans.
How similar studies have gone: Preliminary findings in related pediatric populations suggest genetic and environmental data can improve prediction of pollution-related asthma events, supporting potential utility of this approach.
Where this research is happening
-
Children's Hosp of Philadelphia
Philadelphia, United States Active
Researchers
- Principal investigator: Kelchtermans, Jelte — Children's Hosp of Philadelphia
- Study coordinator: Kelchtermans, Jelte
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.