T-Cell Plasticity and Treatment Resistance in Atopic Dermatitis
Official title: T-cell plasticity mediating treatment resistance and side effects in atopic dermatitis
Funded at Icahn School of Medicine at Mount Sinai · NIH-11389364 · Data updated 2026-11-12
A study exploring how certain immune cells change their behavior in people with atopic dermatitis and how this influences treatment responses and side effects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2025 |
| Project end | August 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $500,516 |
| NIH project number | 5R01AR083960-02 |
| Project ID | NIH-11389364 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with atopic dermatitis who are candidates for or currently receiving dupilumab or similar therapies.
✕Less likely to help
Patients with atopic dermatitis not undergoing dupilumab-type therapies or not contributing samples may not directly benefit from this study.
What this research studies
This project focuses on people with atopic dermatitis and investigates why some patients do not respond well to dupilumab and why some develop inflammatory side effects. Researchers will analyze immune cells from skin and blood to understand how Type 2 inflammation interacts with other immune pathways and how T cells may shift heritages (plasticity) during treatment. The goal is to identify markers and mechanisms that predict non-response or paradoxical inflammation so future therapies can be more effective and safer. The study uses patient-derived samples and clinical data to connect immune biology with real-world treatment outcomes.
Why it matters
Potential benefit: If successful, this work could lead to better, more personalized treatments for atopic dermatitis and fewer adverse inflammatory effects.
How similar studies have gone: Previous work has linked immune cell plasticity to treatment responses, but this project aims to clarify mechanisms specific to dupilumab resistance and related side effects.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Brunner, Patrick — Icahn School of Medicine at Mount Sinai
- Study coordinator: Brunner, Patrick
Related research
Other NIH-funded projects on the same topics.
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Stopping Atopic Dermatitis and Allergy: Preventing Food Allergy by Protecting the Skin
A large study in infants at high risk for allergies tests whether using a skin barrier cream together with early, proactive skin care can prevent peanut allergy and other food allergies.
-
SEAL Study: Preventing peanut allergy by protecting baby skin
This trial tests whether using a skin-emollient and proactive skin steroids early in life can prevent peanut allergy in high-risk infants.
-
SEAL Study: Prevent allergy by protecting the baby’s skin
A very young group of high-risk babies will try a early skin-care plan to reduce eczema and prevent peanut allergy.
-
Understanding how skin fungi affect atopic dermatitis in adults
A study will look at how the skin's fungal community influences atopic dermatitis in adults and whether this understanding could lead to new treatments.
-
Preventing eczema-related allergies by strengthening infants' skin barrier
This project will see if using a trilipid skin cream plus proactive mild topical steroids in infants with early dry skin or eczema lowers their chances of developing food allergies.
-
Personalized predictions for how atopic dermatitis may progress in kids and teens
A patient-friendly plan to forecast how early-onset eczema might evolve in children and young people using simple health clues and data from diverse settings.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.