Neural repair for chronic incomplete cervical spinal cord injury with NgR blockade plus rehab

Who could benefit from this research

What this research studies

This project tests a treatment that blocks the NgR1 pathway to promote nerve growth and pairing it with structured rehab to improve motor function in people with chronic cervical spinal cord injuries. It builds on prior safety data from early human work and emphasizes combining drug therapy with physical therapy in a double-blind, randomized, placebo-controlled study. Participants will receive AXER-204 or placebo alongside rehabilitative training, with safety as the primary concern and motor outcomes as key measures. If successful, this could offer a new way to enhance neural repair and daily function for affected individuals.

Why it matters

Where this research is happening

• Yale University
  New Haven, United States Active

Researchers

• Principal investigator: Strittmatter, Stephen M — Yale University
• Study coordinator: Strittmatter, Stephen M

Related research

Other NIH-funded projects on the same topics.

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• Combining breathing therapies to help restore breathing after neck-level spinal cord injury

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  NIH research University of Florida · Gainesville, United States · NIH-11335738

• Transplanting Lab-Grown Human Neurons to Help cervical spinal cord injuries

  Researchers are testing whether transplanting lab-made human neurons into the neck portion of the spinal cord can improve arm and hand function after injury.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11297537

• Using a mobile robot to help people with severe spinal cord injuries live more independently

  This study is working on a friendly robot that can help people with tetraplegia do everyday tasks like bathing, dressing, and eating, making life a little easier and more independent while also supporting their emotional needs.

  NIH research Charles River Analytics, INC. · Cambridge, United States · NIH-11180646

• Improving breathing recovery after cervical spinal cord injury

  This study is looking at new ways to help people with cervical spinal cord injuries breathe better by combining special breathing exercises with short periods of low oxygen, aiming to boost their recovery and strengthen their breathing muscles.

  NIH research University of Florida · Gainesville, United States · NIH-11106271

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.