Sodium in the Skin and Atopic Dermatitis
Official title: Sodium in the Skin and Atopic Dermatitis: The SIS-AD Study
Funded at University of California, San Francisco · NIH-11413363 · Data updated 2026-11-12
This grant looks at how salt in the skin relates to eczema and whether reducing salt could help people with atopic dermatitis.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 22, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $674,906 |
| NIH project number | 5R01AR082831-04 |
| Project ID | NIH-11413363 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with atopic dermatitis who have variable disease activity and are able to adhere to dietary or skin-care interventions studied.
✕Less likely to help
People with atopic dermatitis who cannot follow dietary changes or do not have skin barrier issues may see limited benefit.
What this research studies
The project explores how excess salt in the skin, linked to skin barrier problems, might worsen eczema and how reducing dietary salt or skin salt storage could improve symptoms. Researchers will examine skin sodium levels, barrier function, and diet, and will see how these factors relate to disease severity over time. This work could lead to practical advice for patients about diet and skin care to manage flares and persistence of atopic dermatitis.
Why it matters
Potential benefit: If successful, it could lead to new dietary or topical strategies to lessen eczema severity and improve quality of life for patients with atopic dermatitis.
How similar studies have gone: Previous research suggests skin sodium can influence inflammatory pathways, but this specific link to eczema and salt reduction is an area of active investigation.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Abuabara, Katrina Elaine — University of California, San Francisco
- Study coordinator: Abuabara, Katrina Elaine
Related research
Other NIH-funded projects on the same topics.
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Stopping Atopic Dermatitis and Allergy: Preventing Food Allergy by Protecting the Skin
A large study in infants at high risk for allergies tests whether using a skin barrier cream together with early, proactive skin care can prevent peanut allergy and other food allergies.
-
SEAL Study: Preventing peanut allergy by protecting baby skin
This trial tests whether using a skin-emollient and proactive skin steroids early in life can prevent peanut allergy in high-risk infants.
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SEAL Study: Prevent allergy by protecting the baby’s skin
A very young group of high-risk babies will try a early skin-care plan to reduce eczema and prevent peanut allergy.
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Understanding how skin fungi affect atopic dermatitis in adults
A study will look at how the skin's fungal community influences atopic dermatitis in adults and whether this understanding could lead to new treatments.
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Preventing eczema-related allergies by strengthening infants' skin barrier
This project will see if using a trilipid skin cream plus proactive mild topical steroids in infants with early dry skin or eczema lowers their chances of developing food allergies.
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Personalized predictions for how atopic dermatitis may progress in kids and teens
A patient-friendly plan to forecast how early-onset eczema might evolve in children and young people using simple health clues and data from diverse settings.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.