Short Course vs Standard Course Antifungal Therapy for Pediatric Candidemia
Official title: Short Course Versus Standard Course Antifungal Therapy for Pediatric Candidemia: A Multi-Center Randomized Controlled Trial
Funded at Arkansas Children's Hospital Res Inst · NIH-11412607 · Data updated 2026-11-12
A pediatric-focused clinical trial tests whether a shorter duration of antifungal therapy after initial improvement is as good as the standard 14-day approach for kids with candidemia.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Arkansas Children's Hospital Res Inst NIH-funded |
| Lab location | 1 site (Little Rock, United States) |
| Project start | August 5, 2022 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $1,210,544 |
| NIH project number | 5R01AI170385-05 |
| Project ID | NIH-11412607 on NIH RePORTER |
Who could benefit from this research
✓Could help
Pediatric patients with invasive candidemia who have shown clinical improvement after an initial 7 days of echinocandin therapy.
✕Less likely to help
Children whose disease does not respond to initial therapy or who have complicated infections may not benefit from a shorter course.
What this research studies
This multi-center trial in children with candidemia compares continuing antifungal therapy for seven more days versus stopping after the initial seven days if patients are improving. It builds on adult data and prior pediatric observations suggesting shorter courses may be safe, aiming to provide clear guidance for treatment duration. Parents and clinicians will participate through consent, regular monitoring, and documentation of outcomes like relapse, side effects, and recovery. The study uses randomized assignment to ensure unbiased comparison and will enroll patients across multiple centers to reflect real-world pediatric care.
Why it matters
Potential benefit: If shorter duration is found to be effective, children could receive effective treatment with fewer days of medication and potentially fewer side effects.
How similar studies have gone: There is precedent in bacterial infections showing safe shorter courses, but this is a pioneering study for invasive fungal disease in children.
Where this research is happening
-
Arkansas Children's Hospital Res Inst
Little Rock, United States Active
Researchers
- Principal investigator: Steinbach, William J — Arkansas Children's Hospital Res Inst
- Study coordinator: Steinbach, William J
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Shorter antifungal treatment for kids with candidemia
A multi-center pediatric trial tests whether a shorter, 7 extra days of antifungal therapy after an initial 7 days is just as good as the standard 14-day approach for kids with candidemia who are improving on echinocandin therapy.
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Short Course vs Standard Course Antifungal Therapy for Pediatric Candidemia
This study tests whether a shorter 7-day total antifungal treatment after an initial 7 days of echinocandin therapy is as effective as the usual 14-day course for children with candidemia.
-
Shorter antifungal treatment for kids with candidemia
A multi-center study tests whether kids with candidemia can finish treatment earlier after an initial week of antifungal therapy than the standard two weeks total.
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Shorter antifungal treatment for kids with candidemia
This study tests whether children with candidemia can finish treatment after 7 days of an echinocandin if they are improving, instead of completing a full 14 days.
-
Shorter antifungal course for kids with candidemia
A multi-center study tests whether 7 extra days of antifungal therapy after an initial week of treatment can be shortened safely for children with candidemia.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.