Metabolic signatures that predict outcomes in children with Crohn's
Population-Based Characterization of Metabolic Pathways to Predict Pediatric Crohn's Disease Outcomes
['FUNDING_R01'] · DUKE UNIVERSITY · NIH-11371199
This project looks at metabolism patterns in children with Crohn's disease to help predict how their condition will progress and respond to treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-11371199 on ClinicalTrials.gov |
What this research studies
If your child has Crohn's, researchers will analyze gene activity from blood and tissue samples to find metabolic patterns linked to worse outcomes. They will combine data from many children across populations and use computer models to map changes in lipids, amino acids, and other metabolic pathways. The team will link those metabolic signatures to disease subtypes, structural complications, and treatment responses. The aim is to create markers that could help doctors choose the right level of therapy for each child.
Who could benefit from this research
Good fit: Children diagnosed with pediatric Crohn's disease (especially young children and those within typical pediatric age ranges) would be the ideal candidates for contributing data or samples.
Not a fit: People without Crohn's disease or adults with only adult-onset Crohn's may not directly benefit from this pediatric-focused work, and it is not a treatment that provides immediate clinical benefit to participants.
Why it matters
Potential benefit: If successful, this work could help doctors predict which children are at higher risk of progression and tailor treatments to avoid unnecessary side effects.
How similar studies have performed: Previous studies have found metabolic changes in Crohn's and early laboratory work suggests targeting some pathways (for example the mevalonate pathway) may help, but large-scale clinical validation is still limited.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SYED, SANA — DUKE UNIVERSITY
- Study coordinator: SYED, SANA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autoimmune Diseases