Romosozumab to Improve Bone Density and Structure in Chronic SCI
Official title: Romosozumab to Improve Bone Mineral Density and Architecture in Chronic SCI
Funded at James J Peters VA Medical Center · NIH-11322558 · Data updated 2026-11-12
A study tests a dual drug approach to strengthen bones in adults with long-standing spinal cord injury to help prevent fractures and improve daily living.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James J Peters VA Medical Center NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | June 1, 2020 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| NIH project number | 5I01RX003415-07 |
| Project ID | NIH-11322558 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with chronic spinal cord injury who have significant bone loss and are at risk for fractures.
✕Less likely to help
Individuals without chronic SCI bone loss or those unable to participate in the intervention due to medical contraindications.
What this research studies
People with chronic spinal cord injury often lose bone mass and bone structure, leading to fragile bones and easy fractures. This project will test a two-drug strategy aimed at increasing bone formation and reducing bone loss below the injury. If successful, stronger bones could mean safer participation in daily activities and better quality of life, including the ability to move more confidently and participate in the community. The work builds on preclinical evidence suggesting anti-sclerostin therapy can restore bone density and improve bone quality after spinal injury.
Why it matters
Potential benefit: Potentially stronger bones and fewer fractures for people with chronic SCI, improving independence and safety in daily activities.
How similar studies have gone: Preclinical data in animal models showed restoration of bone density and improved bone strength with anti-sclerostin therapy after spinal injury.
Where this research is happening
-
James J Peters VA Medical Center
Bronx, United States Active
Researchers
- Principal investigator: Cardozo, Christopher P — James J Peters VA Medical Center
- Study coordinator: Cardozo, Christopher P
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.