Immune system changes in Gulf War Veterans Illnesses and potential treatments
Official title: CMA: Immune/inflammatory priming in exacerbating responses to GWVI stressors: implications for GWVI treatments
Funded at James J Peters VA Medical Center · NIH-11594967 · Data updated 2026-11-12
This NIH grant aims to study how immune and inflammatory processes contribute to Gulf War Veterans Illnesses and to develop new treatment approaches.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | James J Peters VA Medical Center NIH-funded |
| Lab location | 1 site (Bronx, United States) |
| Project start | July 1, 2019 |
| Project end | June 30, 2027 |
| Funding year | 2026 |
| NIH project number | 5I01BX004583-08 |
| Project ID | NIH-11594967 on NIH RePORTER |
Who could benefit from this research
✓Could help
This grant research is not a current clinical trial, but findings aim to inform future patient-directed studies in Gulf War Veterans with similar symptoms.
✕Less likely to help
Participants in this project may be limited to animal models and preclinical experiments without direct patient involvement.
What this research studies
Researchers will combine preclinical studies and experimental models to understand why Gulf War Veterans’ Illnesses involve persistent immune activation. The work builds a coordinated program across VA centers to connect laboratory findings with potential therapies. The effort focuses on how prior exposure to Gulf War toxins may lower immune thresholds and drive sustained symptoms like cognitive issues, fatigue, and mood changes.
Why it matters
Potential benefit: If successful, the project could lead to new therapeutic strategies that target immune pathways for Gulf War Veterans Illnesses.
How similar studies have gone: Prior research indicates immune dysregulation plays a role in Gulf War-related illnesses, supporting a potential translational path for therapies.
Where this research is happening
-
James J Peters VA Medical Center
Bronx, United States Active
Researchers
- Principal investigator: Pasinetti, Giulio Maria — James J Peters VA Medical Center
- Study coordinator: Pasinetti, Giulio Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.