Role of purinergic signaling in diabetic bladder dysfunction
Official title: Role of Urothelial Purinergic Signaling in Diabetic Bladder Dysfunction
Funded at University of Nevada Reno · NIH-11416397 · Data updated 2026-11-12
A study in mouse models of type 2 diabetes will explore how purinergic signaling in the bladder lining may contribute to bladder dysfunction.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project start | January 9, 2020 |
| Project end | September 14, 2028 |
| Funding year | 2026 |
| Award (this year) | $615,612 |
| NIH project number | 4R01DK119482-06 |
| Project ID | NIH-11416397 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with type 2 diabetes who may later benefit from therapies addressing bladder dysfunction.
✕Less likely to help
Patients without bladder symptoms or without diabetes may not directly benefit from this research.
What this research studies
In this project, researchers will examine the cellular and molecular pathways of extracellular purinergic signaling in the bladder’s urothelium and surrounding tissue using two mouse models of type 2 diabetes with obesity. They will build on prior findings about ATP degradation, urothelial enzymes, and how these factors differ between the bladder lining and deeper tissues. The work involves pilot data showing altered ATP/adenosine levels with bladder enlargement and reduced activity, guiding a targeted investigation into what causes purine imbalance in the diabetic bladder. The team will use advanced analytical approaches to pinpoint mechanisms that could be targeted to improve bladder function in diabetes.
Why it matters
Potential benefit: If successful, the research could identify new targets to treat or prevent bladder dysfunction in people with type 2 diabetes.
How similar studies have gone: Preliminary studies have shown purinergic imbalances in the diabetic bladder, supporting further exploration.
Where this research is happening
-
University of Nevada Reno
Reno, United States Active
Researchers
- Principal investigator: Mutafova-Yambolieva, Violeta N. — University of Nevada Reno
- Study coordinator: Mutafova-Yambolieva, Violeta N.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.