Molecular details of AKAP signaling and how it directs cell behavior
Official title: Molecular mechanisms of AKAP-mediated signaling compartmentalization and functional diversity
Funded at University of Nevada Reno · NIH-11426421 · Data updated 2026-11-12
A clinician-friendly look at how AKAP proteins organize cell signaling to influence disease-related cell functions and how new targeted approaches might control these signals.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nevada Reno NIH-funded |
| Lab location | 1 site (Reno, United States) |
| Project start | August 1, 2026 |
| Project end | March 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $361,519 |
| NIH project number | 1R35GM165434-01 |
| Project ID | NIH-11426421 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research is basic science; direct patient recruitment is not described in the grant.
✕Less likely to help
Healthy individuals or patients not affected by the studied signaling pathways may not benefit directly.
What this research studies
This project studies how a family of AKAP proteins organizes signaling in cells and how this organization affects disease-related cell functions. Researchers will map where AKAPs bring together enzymes and substrates in different cell compartments and how these arrangements change signaling outcomes. They also plan to test targeted ways to influence signaling at specific AKAP complexes, with the goal of reducing unwanted effects on other cell processes. The work combines molecular biology with approaches aimed at making interventions more precise at the subcellular level. Over five years, the team hopes to clarify key mechanisms and lay groundwork for focused therapeutics that minimize off-target side effects.
Why it matters
Potential benefit: If successful, this work could lead to more precise therapies that modulate disease-relevant cell signaling with fewer side effects.
How similar studies have gone: Prior work shows that targeting signaling at specific protein complexes can change outcomes, supporting a path to targeted therapies.
Where this research is happening
-
University of Nevada Reno
Reno, United States Active
Researchers
- Principal investigator: Omar, Mitchell Hamed — University of Nevada Reno
- Study coordinator: Omar, Mitchell Hamed
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.