Role of endolysosomal damage in stroke brain injury
Official title: The Role of Lysosomal Membrane Permeabilization and Cathepsin B Release in Stroke Brain Injury
Funded at University of California, San Diego · NIH-11126891 · Data updated 2026-11-12
A scientist is testing how damage to a cell’s lysosome system contributes to brain injury after a stroke, with the goal of finding new ways to protect brain cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $500,642 |
| NIH project number | 5R01NS129553-03 |
| Project ID | NIH-11126891 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research uses mouse models and cellular systems; it does not require patient participation.
✕Less likely to help
Patients will not directly participate in this study.
What this research studies
This project studies how endolysosomes and the enzymes inside them behave after ischemic brain injury, using mouse models that lack NSF in neurons to mimic the cellular chaos seen after stroke. Researchers will examine how the endolysosome to lysosome fusion affects breakdown of waste materials and neuronal survival. By mapping these pathways, the work aims to identify targets that could reduce brain damage and improve recovery after stroke.
Why it matters
Potential benefit: If successful, the findings could point to new approaches to limit brain injury after stroke and inform future therapies.
How similar studies have gone: Prior work has linked endolysosomal dysfunction to neuronal death in stroke models, supporting the potential for translational impact.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Hu, Bingren — University of California, San Diego
- Study coordinator: Hu, Bingren
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.