Investigating how lysosomal damage affects brain injury after a stroke
Official title: The Role of Lysosomal Membrane Permeabilization and Cathepsin B Release in Stroke Brain Injury
Funded at University of California, San Diego · NIH-10872293 · Data updated 2026-11-12
This study is looking at how damage to tiny parts of brain cells affects recovery after a stroke, using special mice to see how missing proteins can lead to cell death, with the hope of finding new ways to help people heal better after a stroke.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $508,648 |
| NIH project number | 5R01NS129553-02 |
| Project ID | NIH-10872293 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who have experienced a stroke or are at risk of stroke-related brain injuries.
✕Less likely to help
Patients with non-ischemic brain injuries or those who have not experienced a stroke may not benefit from this research.
What this research studies
This research focuses on understanding the role of lysosomal damage in brain injuries caused by strokes. It examines how the endolysosomal system, which includes structures like late endosomes and lysosomes, is affected during ischemic events. The study uses a specialized mouse model to explore how deficiencies in certain proteins lead to neuronal death and the accumulation of damaged cellular structures. By uncovering these mechanisms, the research aims to identify potential therapeutic targets for improving recovery after stroke.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance recovery and reduce brain damage in stroke patients.
How similar studies have gone: Other research has shown promising results in understanding lysosomal function in brain injuries, suggesting that this approach could lead to significant advancements in treatment.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Hu, Bingren — University of California, San Diego
- Study coordinator: Hu, Bingren
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.